The presence of Knox Community College in May Pen dates back to the mid - 1980's. Throughout this period professional courses were offered, one being the Certified Professional Secretarial (CPS) course, offered on a part-time basis at various sites in May Pen. These sites include the Mineral Heights Primary School, the May Pen Court House and the Parish Council Building. For one reason or another, these locations were not considered conducive to learning; hence the venues were changed and the programmes offered were eventually discontinued.

However, the late and founding Principal Mrs. Helen Stills did not give up her dreams of having a permanent campus in May Pen and throughout her tenure actively sought an appropriate site for the campus. When the former Free zone Factory site in Foga Road, Denbigh became available; then Principal, Mrs. Hewitt-Buckle seized the opportunity to acquire the premises as the new location of the May Pen campus.

This campus has responded to the needs of the May Pen Community and its environs by offering both full- time and part-time courses in various areas. One area of innovation is the offering of the University Council of Jamaica (UCJ) Accredited Bachelor of Education Degree. The institution remains flexible as it continues to grow and broaden its horizons.